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Book Part Citation Count: 4Advances in Model-Based Testing of Graphical User Interfaces(Elsevier Academic Press inc, 2017) Belli, Fevzi; Beyazit, Mutlu; Budnik, Christof J.; Tuglular, Tugkan; Tuğlular, Tuğkan; Bilgisayar Mühendisliği BölümüGraphical user interfaces (GUIs) enable comfortable interactions of the computer-based systems with their environment. Large systems usually require complex GUIs, which are commonly fault prone and thus are to be carefully designed, implemented, and tested. As a thorough testing is not feasible, techniques are favored to test relevant features of the system under test that will be specifically modeled. This chapter summarizes, reviews, and exemplifies conventional and novel techniques for model-based GUI testing.Article Citation Count: 48Amidoxime functionalized Polymers of Intrinsic Microporosity (PIM-1) electrospun ultrafine fibers for rapid removal of uranyl ions from water(Elsevier Science Bv, 2019) Satilmis, Bekir; Isik, Tugba; Demir, Mustafa M.; Uyar, Tamer; Demir, MustafaThe Polymers of Intrinsic Microporosity (PIM-1) is considered as one of the most promising polymer candidates for adsorption applications owing to its high surface area and the ability to tailor the functionality for the targeted species. This study reports a facile method for the preparation of amidoxime functionalized PIM-1 fibrous membrane (AF-PIM-FM) by electrospinning technique and its practical use for the extraction of U(VI) ions from aqueous systems via column sorption under continuous flow. Fibrous membrane form of amidoxime functionalized PIM-1 (AF-PIM-FM) was prepared by electrospinning method owing to its excellent processability in dimethylformamide. Bead-free and uniform fibers were obtained as confirmed by SEM imaging and average fiber diameter was 1.69 +/- 0.34 mu m for AF-PIM-FM. In addition, electrospun PIM-1 fibrous membrane (PIM-FM) was prepared as a control group. Structural and thermal characterization of powder and membrane forms of the materials were performed using FT-IR, H-1 NMR, XPS, Elemental analyses, TGA, and DSC. The porosity of the samples was measured by N-2 sorption isotherms confirming amidoxime PIM-1 still maintain their porosity after functionalization. Amidoxime functionality along with membrane structure makes AF-PIM-FM a promising material for uranyl adsorption. First, a comparison between powder and membrane form of amidoxime functionalized PIM-1 was investigated using batch adsorption process. Although membrane form has shown slightly lower adsorption performance in the batch adsorption process, the advantage of using the membrane in column adsorption processes makes membrane form more feasible for real applications. In addition, amidoxime modification enhanced the uranium adsorption ability of PIM-FM up to 20 times. The effect of initial concentration and pH were investigated along with regeneration of the adsorbents. AF-PIM-FM was successfully used for five adsorption-desorption cycles without having any damage on the fibrous structure.Article Citation Count: 12Anomalous transmittance of polystyrene-ceria nanocomposites at high particle loadings(Royal Soc Chemistry, 2013) Parlak, Onur; Demir, Mustafa M.; Demir, MustafaOptical nanocomposites based on transparent polymers and nanosized pigment particles have usually been produced at low particle concentrations due to the undesirable optical scattering of the pigment particles. However, the contribution of the particles to many physical properties is realized at high concentrations. In this study, nanocomposites were prepared with transparent polystyrene (PS) and organophilic CeO2 nanoparticles using various compositions in which the particle content was up to 95 wt%. The particles, capped by 3-methacryloxypropyltrimethoxysilane (MPS), were dispersed into PS and the transmittance of the spin-coated composite films was examined over the UV-visible region. When the particle concentration was <20 wt%, the transmittance of the films showed a first-order exponential decay as the Rayleigh scattering theory proposes. However, a positive deviation was observed from the decay function for higher particle contents. The improvement in transmittance may be a consequence of interference in the multiple scattering of light by the quasi-ordered internal microstructure that gradually develops as the particle concentration increases.Article Citation Count: 52Anti-proliferative, apoptotic and signal transduction effects of hesperidin in non-small cell lung cancer cells(Springer, 2015) Cincin, Zeynep Birsu; Unlu, Miray; Kiran, Bayram; Bireller, Elif Sinem; Baran, Yusuf; Cakmakoglu, Bedia; Baran, YusufHesperidin, a glycoside flavonoid, is thought to act as an anti-cancer agent, since it has been found to exhibit both pro-apoptotic and anti-proliferative effects in several cancer cell types. The mechanisms underlying hesperidin-induced growth arrest and apoptosis are, however, not well understood. Here, we aimed to investigate the anti-proliferative and apoptotic effects of hesperidin on non-small cell lung cancer (NSCLC) cells and to investigate the mechanisms involved. The anti-proliferative and apoptotic effects of hesperidin on two NSCLC-derived cell lines, A549 and NCI-H358, were determined using a WST-1 colorimetric assay, a LDH cytotoxicity assay, a Cell Death Detection assay, an AnnexinV-FITC assay, a caspase-3 assay and a JC-1 assay, respectively, all in a time- and dose-dependent manner. As a control, non-cancerous MRC-5 lung fibroblasts were included. Changes in whole genome gene expression profiles were assessed using an Illumina Human HT-12v4 beadchip microarray platform, and subsequent data analyses were performed using an Illumina Genome Studio and Ingenuity Pathway Analyser (IPA). We found that after hesperidin treatment, A549 and NCI-H358 cells exhibited decreasing cell proliferation and increasing caspase-3 and other apoptosis-related activities, in conjunction with decreasing mitochondrial membrane potential activities, in a dose- and time-dependent manner. Through a GO analysis, by which changes in gene expression profiles were compared, we found that the FGF and NF-kappa B signal transduction pathways were most significantly affected in the hesperidin treated NCI-H358 and A549 NSCLC cells. Our results indicate that hesperidin elicits an in vitro growth inhibitory effect on NSCLC cells by modulating immune response-related pathways that affect apoptosis. When confirmed in vivo, hesperidin may serve as a novel anti-proliferative agent for non-small cell lung cancer.Article Citation Count: 17Apoptotic effects of non-edible parts of Punica granatum on human multiple myeloma cells(Sage Publications Ltd, 2016) Kiraz, Yagmur; Neergheen-Bhujun, Vidushi S.; Rummun, Nawraj; Baran, Yusuf; Baran, YusufMultiple myeloma is of great concern since existing therapies are unable to cure this clinical condition. Alternative therapeutic approaches are mandatory, and the use of plant extracts is considered interesting. Punica granatum and its derived products were suggested as potential anticancer agents due to the presence of bioactive compounds. Thus, polypenolic-rich extracts of the non-edible parts of P. granatum were investigated for their antiproliferative and apoptotic effects on U266 multiple myeloma cells. We demonstrated that there were dose-dependent decreases in the proliferation of U266 cells in response to P. granatum extracts. Also, exposure to the extracts triggered apoptosis with significant increases in loss of mitochondrial membrane potential in U266 cells exposed to the leaves and stem extracts, while the flower extract resulted in slight increases in loss of MMP. These results were confirmed by Annexin-V analysis. These results documented the cytotoxic and apoptotic effects of P. granatum extracts on human U266 multiple myeloma cells via disruption of mitochondrial membrane potential and increasing cell cycle arrest. The data suggest that the extracts can be envisaged in cancer chemoprevention and call for further exploration into the potential application of these plant parts.Article Citation Count: 30Apoptotic Effects of Quercitrin on DLD-1 Colon Cancer Cell Line(Frontiers Media Sa, 2015) Cincin, Zeynep Birsu; Unlu, Miray; Kiran, Bayram; Bireller, Elif Sinem; Baran, Yusuf; Cakmakoglu, Bedia; Baran, YusufQuercetin, which is the most abundant bioflavonoid compound, is mainly present in the glycoside form of quercitrin. Although different studies indicated that quercitrin is a potent antioxidant, the action of this compound is not well understood. In this study, we investigated whether quercitrin has apoptotic and antiproliferative effects in DLD-1 colon cancer cell lines. Time and dose dependent antiproliferative and apoptotic effects of quercitrin were subsequently determined by WST-1 cell proliferation assay, lactate dehydrogenase (LDH) cytotoxicity assay, detection of nucleosome enrichment factor, changes in caspase-3 activity, loss of mitochondrial membrane potential (MMP) and also the localization of phosphatidylserine (PS) in the plasma membrane. There were significant increases in caspase-3 activity, loss of MMP, and increases in the apoptotic cell population in response to quercitrin in DLD-1 colon cancer cells in a time- and dose-dependent manner. These results revealed that quercitrin has antiproliferative and apoptotic effects on colon cancer cells. Quercitrin activity supported with in vivo analyses could be a biomarker candicate for early colorectal carcinoma.Conference Object Citation Count: 1Application of Human-Robot Interaction Features to Design and Purchase Processes of Home Robots(Springer international Publishing Ag, 2021) Yapici, Nur Beril; Tuglular, Tugkan; Basoglu, Nuri; Tuğlular, Tuğkan; Bilgisayar Mühendisliği BölümüProduction of home robots, such as robotic vacuum cleaners, currently focuses more on the technology and its engineering than the needs of people and their interaction with robots. An observation supporting this view is that the home robots are not customizable. In other words, buyers cannot select the features and built their home robots to order. Stemmed from this observation, the paper proposes an approach that starts with a classification of features of home robots. This classification concerns robot interaction with humans and the environment, a home in our case. Following the classification, the proposed approach utilizes a new hybrid model based on a built-to-order model and dynamic eco-strategy explorer model, enabling designers to develop a production line and buyers to customize their home robots with the classified features. Finally, we applied the proposed approach to robotic vacuum cleaners. We developed a feature model for robotic vacuum cleaners, from which we formed a common uses scenario model.Article Citation Count: 0Application of the Law of Minimum and Dissimilarity Analysis to Regression Test Case Prioritization(Ieee-inst Electrical Electronics Engineers inc, 2023) Ufuktepe, Ekincan; Tuglular, Tugkan; Tuğlular, Tuğkan; Bilgisayar Mühendisliği BölümüRegression testing is one of the most expensive processes in testing. Prioritizing test cases in regression testing is critical for the goal of detecting the faults sooner within a large set of test cases. We propose a test case prioritization (TCP) technique for regression testing called LoM-Score inspired by the Law of Minimum (LoM) from biology. This technique calculates the impact probabilities of methods calculated by change impact analysis with forward slicing and orders test cases according to LoM. However, this ordering doesn't consider the possibility that consecutive test cases may be covering the same methods repeatedly. Thereby, such ordering can delay the time of revealing faults that exist in other methods. To solve this problem, we enhance the LoM-Score TCP technique with an adaptive approach, namely with a dissimilarity-based coordinate analysis approach. The dissimilarity-based coordinate analysis uses Jaccard Similarity for calculating the similarity coefficients between test cases in terms of covered methods and the enhanced technique called Dissimilarity-LoM-Score (Dis-LoM-Score) applies a penalty with respective on the ordered test cases. We performed our case study on 10 open-source Java projects from Defects4J, which is a dataset of real bugs and an infrastructure for controlled experiments provided for software engineering researchers. Then, we hand-seeded multiple mutants generated by Major, which is a mutation testing tool. Then we compared our TCP techniques LoM-Score and Dis-LoM-Score with the four traditional TCP techniques based on their Average Percentage of Faults Detected (APFD) results.Article Citation Count: 38Autologous rabbit adipose tissue-derived mesenchymal stromal cells for the treatment of bone injuries with distraction osteogenesis(Elsevier Sci Ltd, 2013) Sunay, Ozgur; Can, Geylani; Cakir, Zeynep; Denek, Ziya; Kozanoglu, Ilknur; Erbil, Guven; Baran, Yusuf; Baran, YusufBackground aims. Adipose tissue-derived mesenchymal stromal cells (MSCs) have a higher capacity for proliferation and differentiation compared with other cell lineages. Although distraction osteogenesis is the most important therapy for treating bone defects, this treatment is restricted in many situations. The aim of this study was to examine the therapeutic potential of adipose tissue-derived MSCs and osteoblasts differentiated from adipose tissue-derived MSCs in the treatment of bone defects. Methods. Bone defects were produced in the tibias of New Zealand rabbits that had previously undergone adipose tissue extraction. Tibial osteotomy was performed, and a distractor was placed on the right leg of the rabbits. The rabbits were placed in control (group I), stem cell (group II) and osteoblast-differentiated stem cell (group III) treatment groups. The rabbits were sacrificed, and the defect area was evaluated by radiologic, biomechanical and histopathologic tests to examine the therapeutic effects of adipose tissue-derived MSCs. Results. Radiologic analyses revealed that callus density and the ossification rate increased in group III compared with group I and group II. In biomechanical tests, the highest ossification rate was observed in group III. Histopathologic studies showed that the quality of newly formed bone and the number of cells active in bone formation were significantly higher in group III rabbits compared with group I and group II rabbits. Conclusions. These data reveal that osteoblasts differentiated from adipose tissue-derived MSCs shorten the consolidation period of distraction osteogenesis. Stem cells could be used as an effective treatment for bone defects.Conference Object Citation Count: 0Automatic Code Generation with Document Responsibility Collaboration Modelling Method(Ieee, 2020) Tuglular, Tugkan; Leblebici, Onur; Tuğlular, Tuğkan; Bilgisayar Mühendisliği BölümüUML is highly preferred for design in current software development approaches. However, the conceptual gap between entities in business processes and classes in UML designs is not small. To reduce this gap, this paper proposes using documents that are vital to every business. The proposed new method called Document Responsibility Collaboration puts the concept of documents at the center. In the proposed method, documents are meta-models of classes in terms of programming, and at the same time, they are meta-models of relationships in terms of permanence. The proposed Document Responsibility Collaboration method uses the domain concept in which domains are made up of documents, and a document defined in a domain can work with another document in any domain to fulfill its responsibility. Document Responsibility Collaboration method defines a process, which starts at the transition from analysis to design phase and continues to the code generation phase. An example from the order management domain is provided to validate the recommended method.Article Citation Count: 42Bioactive, functional and edible film-forming properties of isolated hazelnut (Corylus avellana L.) meal proteins(Elsevier Sci Ltd, 2014) Aydemir, Levent Yurdaer; Gokbulut, Aysun Adan; Baran, Yusuf; Yemenicioglu, Ahmet; Baran, YusufThis study aimed characterization of bioactive, functional and edible film making properties of isolated proteins from untreated (HPI), hot extracted (HPI-H), acetone washed (HPI-AW), and acetone washed and hot extracted (HPC-AW-H) hazelnut meals. The most bioactive protein extract was HPC-AW-H, followed by HPI-AW, HPI-H and HPI, based on antioxidant activity (TEAC and ORAC: 158-461 mmol Trolox/kg), iron chelation (60.7-126.7 mmol EDTA/kg), angiotensin-converting enzyme inhibition (IC50: 0.57-1.0 mg/mL) and antiproliferative activity on colon cancer cells (IC50: 3.0-4.6 mg/ml). Protein contents of HPI, HPI-H and HPI-AW (93.3-94.5%) were higher than that of HPC-AW-H (86.0%), but HPC-AW-H showed the best pH-solubility profile. The extracts showed good oil absorption (7.4-9.4 g/g) and foaming, but limited water holding and gelling capacities, and emulsion stability. The protein extracts gave transparent, yellowish to brownish and reddish colored and water soluble edible films. The HPI gave the lightest colored films with acceptable mechanical properties (elongation up to 144% and tensile strength up to 4.9 MPa). 1-D and 2-D electrophoresis clearly showed the molecular and isoelectric profiles of hazelnut proteins. The overall results of this study showed that the bioactive, solubility and gelation properties of hazelnut proteins could be improved by simple processes like acetone washing and/or heat treatment. The hazelnut proteins are valuable as multipurpose food ingredients. (c) 2013 Elsevier Ltd. All rights reserved.Editorial Citation Count: 16Biodiversity, drug discovery, and the future of global health: Introducing the biodiversity to biomedicine consortium, a call to action(Univ Edinburgh, Global Health Soc, 2017) Neergheen-Bhujun, Vidushi; Awan, Almas Taj; Baran, Yusuf; Bunnefeld, Nils; Chan, Kit; Edison Dela Cruz, Thomas; Kagansky, Alexander; Baran, Yusuf[No Abstract Available]Review Citation Count: 4Biodiversity: the overlooked source of human health(Cell Press, 2023) Linhares, Yuliya; Kaganski, Alexander; Agyare, Christian; Kurnaz, Isil A.; Neergheen, Vidushi; Kolodziejczyk, Bartlomiej; Bueso, Yensi FloresBiodiversity is the measure of the variation of lifeforms in a given ecological system. Biodiversity provides ecosystems with the robustness, stability, and re-silience that sustains them. This is ultimately essential for our survival because we depend on the services that natural ecosystems provide (food, fresh water, air, climate, and medicine). Despite this, human activity is driving an unprece-dented rate of biodiversity decline, which may jeopardize the life-support sys-tems of the planet if no urgent action is taken. In this article we show why biodiversity is essential for human health. We raise our case and focus on the biomedicine services that are enabled by biodiversity, and we present known and novel approaches to promote biodiversity conservation.Review Citation Count: 12Bisphosphonate treatment and radiotherapy in metastatic breast cancer(Humana Press inc, 2008) Ural, A. Ugur; Avcu, Ferit; Baran, Yusuf; Baran, YusufPatients with advanced breast cancer frequently develop metastasis to bone. Bone metastasis results in intractable pain and high risk of pathologic fractures due to osteolysis. The treatment of breast cancer patients with bone metastases requires a multidisciplinary approach. Radiotherapy is an established treatment for metastatic bone pain. It may be delivered either as a localized low dose treatment for localized bone pain or systemically for more widespread symptoms. Bisphosphonates have been shown to reduce morbidity and bone pain from bone metastases when given to patients with metastatic bone disease. In vivo studies indicate that early bisphosphonates administration in combination with radiotherapy improves remineralization and restabilization of osteolytic bone metastases in animal tumor models. This review focused on a brief discussion about biology of bone metastases, the effects of radiotherapy and bisphosphonate therapy, and possible mechanisms of combination therapy in metastatic breast cancer patients.Review Citation Count: 46Challenges in the Preparation of Optical Polymer Composites With Nanosized Pigment Particles: A Review on Recent Efforts(Wiley-v C H verlag Gmbh, 2012) Demir, Mustafa M.; Wegner, Gerhard; Demir, MustafaBlends of nanosized pigment particles and polymers are widely believed to offer the potential for the design of novel or at least improved materials. This review critically evaluates the recent literature with regard to the following issues: (a) why and how does the size of the particles matter, (b) what are the requirements to create compatibility between amorphous polymers and nanoparticles, (c) carbon allotropes as nanosized pigments, (d) bulk polymerization of monomer/pigment mixtures, (e) interaction of growing chains with the particles in the polymerization, (f) depletion flocculation as a mechanism to counteract homogeneous distribution of the particles in the polymer matrix and ways to suppress the undesirable flocculation, and (g) optical properties of the blends as well as methods of optical characterization.Article Citation Count: 1Characterization of Sb scaling and fluids in saline geothermal power plants: A case study for Germencik Region (Buyuk Menderes Graben, Turkey)(Pergamon-elsevier Science Ltd, 2021) Tonkul, Serhat; Baba, Alper; Demir, Mustafa M.; Regenspurg, Simona; Demir, MustafaTurkey is located on the seismically active Alpine-Himalayan belt. Although tectonic activity causes seismicity in the Anatolian plate, it also constitutes an important geothermal energy resource. Today, geothermal energy production is heavily concentrated in Turkey's Western Anatolia region. Graben systems in this region are very suitable for geothermal resources. The Buyuk Menderes Graben (BMG) is an area of complex geology with active tectonics and high geothermal potential power. Germencik (Aydin) is located in the BMG, where the geothermal waters include mainly Na-Cl-HCO3 water types. This study examined the stibnite scaling formed in the preheater system of the Germencik Geothermal Field (GGF). The formation of the stibnite scaling on the preheater system dramatically reduces the energy harvesting of the GGF. Considering the stibnite scaling in the surface equipment, the optimum reinjection temperature was determined as 95 degrees C to prevent stibnite scaling in the GGF.Article Citation Count: 34Chemically modified optical fibers in advanced technology: An overview(Elsevier Sci Ltd, 2019) Shukla, S. K.; Kushwaha, Chandra Shekhar; Guner, Tugrul; Demir, Mustafa M.; Demir, MustafaIn recent years, chemically modified optical fibers have widely used for development of several advanced chemical and biosensors, biomedical technology and environmental monitoring. The chemically modified optical fiber bears several valuable properties like energy loss, catalytic behaviour, refractive index, and mechanical strength to advance the optical fiber technology. In this article, we reviewed the chemically-modified optical fiber and their applications in different optical fiber-based technologies. The basics of optical fiber and their modification are discussed along with the adopted methodologies. The advancements in different optical fiber based technologies viz sensing, imaging, tomography, magnetic resonance imaging, photodynamic therapy, optogenics, surgery and environmental monitoring are discussed in the light of the contribution of chemically modified optical fibers. In conclusion, success and challenges for the use of chemically modified-optical fiber are presented on the basis of existing literature.Article Citation Count: 101Chitosan fiber-supported zero-valent iron nanoparticles as a novel sorbent for sequestration of inorganic arsenic(Royal Soc Chemistry, 2013) Horzum, Nesrin; Demir, Mustafa M.; Nairat, Muath; Shahwan, Talal; Demir, MustafaThis study proposes a new sorbent for the removal of inorganic arsenic from aqueous solutions. Monodispersed nano zero-valent iron (nZVI) particles were nucleated at the surface of electrospun chitosan fibers (average fiber diameter of 195 +/- 50 nm) by liquid phase reduction of FeCl3 using NaBH4. The material was characterized using SEM, TGA, XPS, XRD, and FTIR. The diameter of iron nanoparticles was found to vary between 75-100 nm. A set of batch experiments were carried out to elucidate the efficiency of the composite sorbent toward fixation of arsenite and arsenate ions. The ion concentrations in the supernatant solutions were determined using inductively coupled plasma-mass spectrometry (ICP-MS). The results revealed that the chitosan fiber supported nZVI particles is an excellent sorbent material for inorganic arsenic uptake at concentrations ranging from 0.01 to 5.00 mg L-1 over a wide range of pH values. Based on XPS analysis, As(III) was found to undergo oxidation to As(V) upon sorption, while As(V) retained its oxidation state. By virtue of the successful combination of the electrospun fibers' mechanical integrity and the large reactivity of dispersed nZVI particles, the applicability of the resulting sorbent material in arsenic sorption holds broad promise.Article Citation Count: 12Colloidal films of SiO2 in elastomeric polyacrylates by photopolymerization: A strain sensor application(Elsevier Science Sa, 2020) Inci, Ezgi; Topcu, Gokhan; Demir, Mustafa M.; Demir, MustafaThin layer SiO2 colloidal films show angle-dependent coloration (iridescence) based on constructive interference, rather than absorption, without the existence of pigments. The transfer of thin layered colloidal film into a transparent elastomeric matrix maintaining its color may allow the fabrication of colorimetric strain sensors. In this study, trilayer SiO2 colloidal films were prepared by Langmuir-Blodgett deposition using a binary solvent system (chloroform/methanol) and this structure is successfully transferred into poly(ethylene glycol) phenyl ether acrylate elastomer via lateral capillary force. The resulting composite films exhibit iridescence depending on the particle size, therefore, film thickness as similar in mere colloidal films with a slight difference due to change in efficient refractive index (neff). Uniaxial extension of the composite film up to 50 % strain causes a remarkable linear shift in reflection signal from 568 to 496 nm. The change in thickness of the composite film accordingly intercolloidal distance normal to the application of mechanical stretching causes variation of the reflection of light.Article Citation Count: 3Color-Tunable All-Inorganic CsPbBr3 Perovskites Nanoplatelet Films for Photovoltaic Devices(Amer Chemical Soc, 2019) Ozcan, Mehmet; Ozen, Sercan; Topcu, Gokhan; Demir, Mustafa M.; Sahin, Hasan; Demir, MustafaHerein, we demonstrate a novel coating approach to fabricate CsPbBr3 perovskite nanoplatelet film with heat-free process via electrospraying from precursor solution. A detailed study is carried out to determine the effect of various parameters such as ligand concentration, electric field, flow rate, etc. on the optical properties. By controlling the volume ratios of the oleylamine (OAm) and oleic acid (OA), the coalescing and thickness of the resulting nanoplatelets can be readily tuned that results in control over emission in the range of 100 nm without any antisolvent crystallization or heating processes. The varying electrical field and flow rate was found as inefficient on the emission characteristics of the films. In addition, the crystal films were obtained under ambient conditions on the ITO coated glass surfaces as in the desired pattern. As a result, we demonstrated a facile and reproducible way of synthesizing and coating of CsPbBr3 perovskite nanoplatelets which is suitable for large-scale production. In this method, the ability of tuning the degree of quantum confinement for perovskite nanoplatelets is promising approach for the one-step fabrication of crystal films that may enable the use in optoelectronics.