This is a Demo Server. Data inside this system is only for test purpose.

PudMed

Permanent URI for this collectionhttp://65.108.157.135:4000/handle/123456789/13

Browse

Browsing PudMed by Journal "ACS Omega"

Filter results by typing the first few letters
Now showing 1 - 2 of 2
  • Thumbnail Image
    Article
    Development of AB3-Type Novel Phthalocyanine and Porphyrin Photosensitizers Conjugated with Triphenylphosphonium for Higher Photodynamic Efficacy
    (Amer Chemical Soc, 2022) Onal, Emel; Tuncel, Ozge; Vatansever, Ipek Erdogan; Albakour, Mohamad; Celik, Gizem Gumusgoz; Kucuk, Tugba; Ozcelik, Serdar
    There are a number of lipophilic cations that can be chosen; the triphenylphosphonium (TPP) ion is particularly unique for mitochondrion targeting, mainly due to its simplicity in structure and ease to be linked to the target molecules. In this work, mitochondrion-targeted AB3-type novel phthalocyanine and porphyrin photosensitizers (PSs) were synthesized and their photophysical photochemical properties were defined. Fluores-cence quantum yields (phi F) are 0.009, 0.14, 0.13, and 0.13, and the singlet-oxygen quantum yields (phi Delta) are 0.27, 0.75, 0.57, and 0.58 for LuPcPox(OAc), AB3TPP-Pc, AB3TPP-Por-C4, and AB3TPP-Por-C6, respectively. To evaluate the photodynamic efficacy of the TPP-conjugated PS cell viabilities of A549 and BEAS-2B lung cells were comparatively measured and IC-50 values were determined. AB3TPP-Por-C4, AB3TPP-Por-C6, and AB3TPP-Pc compounds compared to the reference molecules ZnPc and H2TPP were found to be highly cytotoxic (sub-micromolar concentration) under the light. LuPcPox(OAc) is the most effective molecule regarding cell killing (the activity). The cell killing of the TPP-conjugated porphyrin derivatives exhibits a similar response compared to LuPcPox(OAc) when the light absorbing factor of the PS is normalized at 660 nm: TPP-conjugated porphyrins absorb less light (lower extinction coefficient) but produce more radical species (higher singlet-oxygen quantum yield) and therefore effectively kill the cells. The singlet oxygen-producing capacity of AB3TPP-Pc is almost 3 times higher compared to LuPcPox(OAc) and 50% more efficient with respect to ZnPc, suggesting that TPP-conjugated phthalocyanine may serve as a good photosensitizer for photodynamic therapy (PDT). The high singlet oxygen generation capacity of these novel TPP-conjugated porphyrin and phthalocyanine PS suggests that they might be useful for PDT requiring lower photosensitizer concentration and reduced energy deposited through less light exposure.
  • Thumbnail Image
    Article
    Investigating the Effects of PA66 Electrospun Nanofibers Layered within an Adhesive Composite Joint Fabricated under Autoclave Curing
    (Amer Chemical Soc, 2023) Esenoglu, Gozde; Tanoglu, Metin; Barisik, Murat; Iplikci, Hande; Yeke, Melisa; Nuhoglu, Kaan; Iris, Mehmet Erdem; Tanoğlu, Metin
    Enhancing the performance of adhesively joined composite components is crucial for various industrial applications. In this study, polyamide 66 (PA66) nanofibers produced by electrospinning were coated on unidirectional carbon/epoxy prepregs to increase the bond strength of the composites. Carbon/epoxy prepregs with/without PA66 nanofiber coating on the bonding region were fabricated using the autoclave, which is often used in the aerospace industry. The single lap shear Charpy impact energy and Mode-I fracture toughness tests were employed to examine the effects of PA66 nanofibers on the mechanical properties of the joint region. Scanning electron microscopy (SEM) was used to investigate the nanofiber morphology and fracture modes. The thermal characteristics of Polyamide 66 nanofibers were explored by using differential scanning calorimetry (DSC). We observed that the electrospun PA66 nanofiber coating on the prepreg surfaces substantially improves the joint strength. Results revealed that the single lap shear and Charpy impact strength values of the composite joint are increased by about 79 and 24%, respectively, by coating PA66 nanofibers onto the joining region. The results also showed that by coating PA66 nanofibers, the Mode-I fracture toughness value was improved by about 107% while the glass transition temperature remained constant.