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    Patent
    Essential oil loaded mucoadhesive nanocomposite delivery system for gastrointestinal system
    (World Intellectual Property Organization, 2016-07-07) Altıok, Duygu; Tıhmınlıoğlu, Funda; Güneş, Suna Seda
    Current treatments for H. pylori infection are not efficient enough due to poor diffusion of antibiotics to mucus layer, low stability, side effects and insufficient residence time of antibiotics in gut, antibiotic resistance of H. pylori and allergy of patients against antibiotics. Therefore, alternative therapies including new drugs and therapeutic approaches with enhanced action and reduced side effects are needed to achieve high eradication rate of the bacteria. This invention is related with eradication and/or prevention therapy of H.pylori that provides better diffusion to mucus layer and stabilization in gastric conditions. This invention comprises the local treatment of H.pylori and/or improving the drug release profiles of encapsulated essential oil within chitosan/nanoclay microspheres which could be located in gastrointestinal system. Therefore, the aim of this invention is to encapsulate essential oil in gastroretentive chitosan/nanoclay spheres which has antimicrobial activity against H.pylori and release in a controlled manner in the prior to art.
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    Patent
    Microfluidic device for investigation of distance dependent interactions in cell biology
    (U.S. Patent and Trademark Office, 2015-04) Pesen Okvur, Devrim; Izmir Institute of Technology
    The invention presents a microfluidic device that provides investigation of distance dependent interactions between cells and various factors. A method that uses the device to determine distance dependent interactions between cells and various factors and agents that can change these interactions is also presented.
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    Patent
    Silicon-based emitter compound
    (Espacenet, 2018) Öner, Saliha; Öner, İlker; Varlıklı, Canan; Jacob, Andreas; Seifermann, Stefan; Volz, Daniel; Orta Doğu Teknik Üniversitesi; Orta Doğu Teknik Üniversitesi; Izmir Institute of Technology; Massachusetts Institute of Technology; Technische Universität Darmstadt; Karlsruhe Institute of Technology
    The present invention relates to emitter compounds E of formula or salts thereof based on a triazine core, substituted with at least one moiety of formula: and at least one donor moiety. Further, the present invention also refers to a light-emitting layer B comprising the emitter compound E and to an opto-electronic device OD comprising such light-emitting layer B. Moreover, the present invention relates to a method for generating light of a desired wavelength range by means of the opto-electronic device OD.
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    Patent
    Three dimensional microfluidic device that determines metastatic capacity and homing choices
    (European Patent Office, 2014) Pesen Okvur, Devrim; Izmir Institute of Technology
    The invention provides a device that mimics the in vivo tumor microenvironment comprising different cell types, matrices, biological molecules and chemicals. All steps of metastasis, namely, angiogenesis, matrix invasion, cell migration, intravasation, circulation, extravasation and new tumor formation, in addition to homing choices of cancer cells can simultaneously and jointly be investigated using the said microfluidic device. The design of the device with multiple adjacent channels comprising 3D cell-laden or cell free matrices(24, 25, 26, 27, 28, 29) neighboring a flow channel (30) allows determination of metastatic capacity and homing choices of cancer cells.