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Izmir Institute of Technology

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Browsing Izmir Institute of Technology by Subject "3D printer"

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    Master Thesis
    Development of 3D printed spectroscopy ınstrumentation for medical applications
    (01. Izmir Institute of Technology, 2020-12) Kanlı, Ali İhsan; Karabudak, Engin; 01. Izmir Institute of Technology
    The aim of this thesis is technically to produce a national production basement on analytical device manufacturing. In addition, recent advances in the evaluation of absorbance, reflection and fluorescence spectrum measurements in the UV-VIS range (vascular volume, oxygenation, extra cellular matrix, metabolic redox states, cellular proliferation) give us valuable measurements about the diagnosis, prognosis and treatment of some cancer types. Thus for every doctor and for every medical laboratory a cheap, portable, handy, and enough accurate UV-VIS spectrometer has become an up to date demand. Therefore production of an analytical VIS-spectrometer is planned as a first step on the way of our aim, by using our laboratory facilities and by using very common optical, electronical, mechanical components in the market around. Optical box design was get from an internet open source and printed in our laboratory by 3D-printer (Stratasys-Objet 30). A general purpose plastic mounting box (15x9x5 cm) is used for electronic part of the spectrometer. These two box is adjusted to each other to become as a single cabinet for spectrometer. Optical components are mounted, aligned and coupled to electronic circuit. PC and Microcontroller programs are written and loaded in our laboratory. During the calibration of our device, its performance is compared with the technical specifications of commercial VIS-spectrometers. As a last step; the produced device is used and tested in our laboratory.
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    Master Thesis
    Fabrication of microfluidic devices via 3D printer
    (Izmir Institute of Technology, 2019-07) Keçili, Seren; Tekin, Hüseyin Cumhur; Bulmuş, Volga
    The purpose of this thesis is to provide easy and rapid prototyping of microfluidic devices using 3D printing technology that overcomes disadvantages of traditional fabrication techniques and also enhanced optical transparency of 3D-printed microfluidic devices fabricated using new bonding strategies. For performance analysis of 3D printer, microfluidic channels and molds having different shape and dimensions were designed and fabricated. After the fabrication process, designed and fabricated channel dimensions were compared. Structures having at least having 50 μm feature were printed successfully. For enhancing transparency of fabricated 3D structures, two different fabrication techniques were developed. In these techniques, 3D structures were bonded on glass substrates with poly (dimethylsiloxane) (PDMS) and Formlabs Clear Resin interlayers. After 3D-printed structures were put on interlayers coated glass slides, they were either remained on coated slides or transferred on new slides. Bonding between 3D structures and glass slides were provided with UV exposure for resin and with elevated temperature for PDMS interlayers. Bonding strength of fabricated channels was investigated for different thicknesses of PDMS and resin interlayers. The bright-field and fluorescence imaging properties of these channels were also analyzed. Proposed fabrication technique showed 2-fold improved bonding strength and comparable bright-field and fluorescence imaging capability with respect to traditional plasma activated PDMS-glass bonding. Furthermore, protein modified glass substrates can be integrated in 3D-printed channels using the presented fabrication technique without disturbing protein functionality. Finally, in order to design a 3D-printed micropump having membranes that can be activated with compressed air, membrane deformation was characterized with different dimension.