Bioactive sphingolipids in docetaxel-induced apoptosis in human prostate cancer cells
| dc.contributor.author | Bassoy, Esen Yonca | |
| dc.contributor.author | Baran, Yusuf | |
| dc.date.accessioned | 2023-11-18T10:06:36Z | |
| dc.date.available | 2023-11-18T10:06:36Z | |
| dc.date.issued | 2012 | |
| dc.description | Bassoy, Esen Yonca/0000-0001-8870-7040; Baran, Yusuf/0000-0002-1056-4673 | en_US |
| dc.description.abstract | In this study, we examined the possible roles of ceramide/sphingosine-1-phosphate and ceramide/glucosyleceramide signaling in docetaxel-induced apoptosis by examining expression levels of the glucosyleceramide synthase and sphingosine kinase-1 and ceramide synthase gene family. As confirmed by isobologram analysis, docetaxel in combination with agents that increase intracellular ceramide levels increased the cytotoxic and apoptotic effects of docetaxel synergistically. More importantly, RT-PCR results revealed that expression levels of glucosyleceramide synthase and sphingosine kinase-1 were downregulated and ceramide synthase genes were upregulated in response to docetaxel. This study identifies mechanisms underlying the involvement of ceramide metabolizing genes in docetaxel-induced apoptosis in prostate cancer cells. (c) 2012 Elsevier Masson SAS. All rights reserved. | en_US |
| dc.description.sponsorship | TUBITAK [109S215]; Turkish Academy of Sciences Outstanding Young Investigator Programme | en_US |
| dc.description.sponsorship | They thank Prof Dr Anne Frary for critically reviewing the manuscript. This study was supported by TUBITAK project number 109S215 to Y.B and by the Turkish Academy of Sciences Outstanding Young Investigator Programme to Y.B. | en_US |
| dc.identifier.citation | 9 | |
| dc.identifier.doi | 10.1016/j.biopha.2011.10.003 | |
| dc.identifier.issn | 0753-3322 | |
| dc.identifier.issn | 1950-6007 | |
| dc.identifier.uri | https://doi.org/10.1016/j.biopha.2011.10.003 | |
| dc.identifier.uri | http://standard-demo.gcris.com/handle/123456789/7012 | |
| dc.language.iso | en | en_US |
| dc.publisher | Elsevier France-editions Scientifiques Medicales Elsevier | en_US |
| dc.relation.ispartof | Biomedicine & Pharmacotherapy | |
| dc.rights | info:eu-repo/semantics/closedAccess | en_US |
| dc.subject | Prostate cancer | en_US |
| dc.subject | Bioactive sphingolipids | en_US |
| dc.subject | Ceramides | en_US |
| dc.subject | Sphingosine kinase | en_US |
| dc.subject | Glucosyle ceramide synthase | en_US |
| dc.subject | Docetaxel | en_US |
| dc.title | Bioactive sphingolipids in docetaxel-induced apoptosis in human prostate cancer cells | en_US |
| dc.type | Article | en_US |
| dspace.entity.type | Publication | |
| gdc.author.id | Bassoy, Esen Yonca/0000-0001-8870-7040 | |
| gdc.author.id | Baran, Yusuf/0000-0002-1056-4673 | |
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| gdc.description.department | Izmir Institute of Technology İYTE | en_US |
| gdc.description.departmenttemp | [Bassoy, Esen Yonca; Baran, Yusuf] Izmir Inst Technol, Dept Mol Biol & Genet, Canc Genet & Mol Hematol Lab, TR-35430 Izmir, Turkey | en_US |
| gdc.description.issue | 2 | en_US |
| gdc.description.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
| gdc.description.scopusquality | Q1 | |
| gdc.description.volume | 66 | en_US |
| gdc.description.wosquality | Q1 | |
| gdc.identifier.pmid | 22326625 | |
| gdc.identifier.wos | WOS:000302420800005 | |
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| gdc.oaire.keywords | Male | |
| gdc.oaire.keywords | Down-Regulation | |
| gdc.oaire.keywords | Antineoplastic Agents | |
| gdc.oaire.keywords | Apoptosis | |
| gdc.oaire.keywords | Glucosylceramides | |
| gdc.oaire.keywords | Sphingosine | |
| gdc.oaire.keywords | Cell Line, Tumor | |
| gdc.oaire.keywords | Humans | |
| gdc.oaire.keywords | Reverse Transcriptase Polymerase Chain Reaction | |
| gdc.oaire.keywords | Prostatic Neoplasms | |
| gdc.oaire.keywords | Drug Synergism | |
| gdc.oaire.keywords | Up-Regulation | |
| gdc.oaire.keywords | Gene Expression Regulation, Neoplastic | |
| gdc.oaire.keywords | Phosphotransferases (Alcohol Group Acceptor) | |
| gdc.oaire.keywords | Glucosyltransferases | |
| gdc.oaire.keywords | Taxoids | |
| gdc.oaire.keywords | Lysophospholipids | |
| gdc.oaire.keywords | Oxidoreductases | |
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| gdc.oaire.relevantdates | published-online:2012-01-25 | |
| gdc.oaire.sciencefields | 03022001 Oncology/Infectious causes of cancer | |
| gdc.oaire.sciencefields | 03 medical and health sciences | |
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