STAT pathway in the regulation of zoledronic acid-induced apoptosis in chronic myeloid leukemia cells
| dc.contributor.author | Kiper, Hatice Demet | |
| dc.contributor.author | Kaymaz, Burcin Tezcanli | |
| dc.contributor.author | Gokbulut, Aysun Adan | |
| dc.contributor.author | Selvi, Nur | |
| dc.contributor.author | Avci, Cigir Biray | |
| dc.contributor.author | Kosova, Buket | |
| dc.contributor.author | Saydam, Guray | |
| dc.date.accessioned | 2023-11-18T10:06:13Z | |
| dc.date.available | 2023-11-18T10:06:13Z | |
| dc.date.issued | 2013 | |
| dc.description | Kosova, Buket/0000-0003-3636-6082; Kartal Yandim, Melis/0000-0003-0573-4276; Avci, Cigir Biray/0000-0001-8251-4520; Sahin, Fahri/0000-0001-9315-8891; Gunduz, Cumhur/0000-0002-6593-3237; tezcanlı kaymaz, burçin/0000-0003-1832-1454; Saydam, Guray/0000-0001-8646-1673; Biray Avcı, Cigir/0000-0001-8251-4520; Yandim, Melis Kartal/0000-0003-0573-4276; adan, aysun/0000-0002-3747-8580; Baran, Yusuf/0000-0002-1056-4673 | en_US |
| dc.description.abstract | In this study, we aimed to evaluate the cytotoxic and apoptotic effects of zoledronic acid on K562 chronic myeloid leukemia (CML) cells and to examine the roles of STAT genes on zoledronic acid-induced apoptosis. The results showed that zoledronic acid decreased proliferation, and induced apoptosis in K562 cells in a dose- and time-dependent manner. mRNA and protein levels of STAT3, -5A and -5B genes were significantly reduced in zoledronic acid-treated K562 cells. These data indicated that STAT inhibition by zoledronic acid may be therapeutic in CML patients following the confirmation with clinical studies. (C) 2013 Elsevier Masson SAS. All rights reserved. | en_US |
| dc.identifier.citation | 12 | |
| dc.identifier.doi | 10.1016/j.biopha.2013.04.006 | |
| dc.identifier.issn | 0753-3322 | |
| dc.identifier.issn | 1950-6007 | |
| dc.identifier.uri | https://doi.org/10.1016/j.biopha.2013.04.006 | |
| dc.identifier.uri | http://standard-demo.gcris.com/handle/123456789/6957 | |
| dc.language.iso | en | en_US |
| dc.publisher | Elsevier France-editions Scientifiques Medicales Elsevier | en_US |
| dc.relation.ispartof | Biomedicine & Pharmacotherapy | |
| dc.rights | info:eu-repo/semantics/openAccess | en_US |
| dc.subject | Chronic myeloid leukemia | en_US |
| dc.subject | Zoledronic acid | en_US |
| dc.subject | STATs | en_US |
| dc.title | STAT pathway in the regulation of zoledronic acid-induced apoptosis in chronic myeloid leukemia cells | en_US |
| dc.type | Article | en_US |
| dspace.entity.type | Publication | |
| gdc.author.id | Kosova, Buket/0000-0003-3636-6082 | |
| gdc.author.id | Kartal Yandim, Melis/0000-0003-0573-4276 | |
| gdc.author.id | Avci, Cigir Biray/0000-0001-8251-4520 | |
| gdc.author.id | Sahin, Fahri/0000-0001-9315-8891 | |
| gdc.author.id | Gunduz, Cumhur/0000-0002-6593-3237 | |
| gdc.author.id | tezcanlı kaymaz, burçin/0000-0003-1832-1454 | |
| gdc.author.id | Baran, Yusuf/0000-0002-1056-4673 | |
| gdc.bip.impulseclass | C5 | |
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| gdc.description.department | Izmir Institute of Technology İYTE | en_US |
| gdc.description.departmenttemp | [Kiper, Hatice Demet] Ege Univ, Sch Med, Dept Internal Med, Izmir, Turkey; [Kaymaz, Burcin Tezcanli; Selvi, Nur; Avci, Cigir Biray; Kosova, Buket; Gunduz, Cumhur] Ege Univ, Sch Med, Dept Med Biol, Izmir, Turkey; [Gokbulut, Aysun Adan; Iskender, Guniz; Yandim, Melis Kartal; Baran, Yusuf] Izmir Inst Technol, Sch Sci, Dept Mol Biol & Genet, TR-35430 Izmir, Turkey; [Sahin, Fahri; Saydam, Guray] Ege Univ, Sch Med, Dept Hematol, Izmir, Turkey | en_US |
| gdc.description.issue | 6 | en_US |
| gdc.description.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
| gdc.description.scopusquality | Q1 | |
| gdc.description.volume | 67 | en_US |
| gdc.description.wosquality | Q1 | |
| gdc.identifier.pmid | 23725755 | |
| gdc.identifier.wos | WOS:000324098000012 | |
| gdc.oaire.accepatencedate | 2013-07-01 | |
| gdc.oaire.accesstype | Gold | |
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| gdc.oaire.keywords | Diphosphonates | |
| gdc.oaire.keywords | Messenger RNA | |
| gdc.oaire.keywords | Imidazoles | |
| gdc.oaire.keywords | Apoptosis | |
| gdc.oaire.keywords | Zoledronic Acid | |
| gdc.oaire.keywords | STAT Transcription Factors | |
| gdc.oaire.keywords | Cell Line, Tumor | |
| gdc.oaire.keywords | Leukemia, Myelogenous, Chronic, BCR-ABL Positive | |
| gdc.oaire.keywords | Humans | |
| gdc.oaire.keywords | K562 Cells | |
| gdc.oaire.keywords | Cell Proliferation | |
| gdc.oaire.keywords | Signal Transduction | |
| gdc.oaire.magid | 2051819087 | |
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| gdc.oaire.relevantdates | created:2013-05-07 | |
| gdc.oaire.relevantdates | published-print:2013-07-01 | |
| gdc.oaire.relevantdates | published-online:2013-05-07 | |
| gdc.oaire.sciencefields | 0301 basic medicine | |
| gdc.oaire.sciencefields | 03022001 Oncology/Infectious causes of cancer | |
| gdc.oaire.sciencefields | 03 medical and health sciences | |
| gdc.oaire.sciencefields | 030104 developmental biology | |
| gdc.oaire.sciencefields | 0302 clinical medicine | |
| gdc.oaire.sciencefields | 030220 oncology & carcinogenesis | |
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