Pesen Okvur, Devrim2023-10-312023-10-312014http://65.108.157.135:4000/handle/123456789/168Three dimensional microfluidic device that determines metastatic capacity and homing choices isimli buluşa ait, European Patent Office tarafından EP2741083A1 numarasıyla verilen patente ilişkin kayıttır.The invention provides a device that mimics the in vivo tumor microenvironment comprising different cell types, matrices, biological molecules and chemicals. All steps of metastasis, namely, angiogenesis, matrix invasion, cell migration, intravasation, circulation, extravasation and new tumor formation, in addition to homing choices of cancer cells can simultaneously and jointly be investigated using the said microfluidic device. The design of the device with multiple adjacent channels comprising 3D cell-laden or cell free matrices(24, 25, 26, 27, 28, 29) neighboring a flow channel (30) allows determination of metastatic capacity and homing choices of cancer cells.eninfo:eu-repo/semantics/openAccessMicrofluidic deviceMetastatic capacityHoming choicesPatenthttps://patents.google.com/patent/EP2741083A1/en