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Citation - WoS: 15
Citation - Scopus: 17
Achieving query performance in the cloud via a cost-effective data replication strategy
(Springer, 2021) Tos, Uras; Mokadem, Riad; Hameurlain, Abdelkader; Ayav, Tolga; Ayav, Tolga; Bilgisayar Mühendisliği Bölümü
Meeting performance expectations of tenants without sacrificing economic benefit is a tough challenge for cloud providers. We propose a data replication strategy to simultaneously satisfy both the performance and provider profit. Response time of database queries is estimated with the consideration of parallel execution. If the estimated response time is not acceptable, bottlenecks are identified in the query plan. Data replication is realized to resolve the bottlenecks. Data placement is heuristically performed in a way to satisfy query response times at a minimal cost for the provider. We demonstrate the validity of our strategy in a performance evaluation study.
Citation - WoS: 41
Citation - Scopus: 45
Advances in Electrospun Fiber-Based Flexible Nanogenerators for Wearable Applications
(Wiley-v C H verlag Gmbh, 2021) Arica, Tugce A.; Isik, Tugba; Guner, Tugrul; Horzum, Nesrin; Demir, Mustafa M.; Demir, Mustafa
In today's digital age, the need and interest in personal and portable electronics shows a dramatic growth trend in daily life parallel to the developments in sensors technologies and the internet. Wearable electronics that can be attached to clothing, accessories, and the human body are one of the most promising subfields. The energy requirement for the devices considering the reduction in device sizes and the necessity of being flexible and light, the existing batteries are insufficient and nanogenerators have been recognized a suitable energy source in the last decade. The mechanical energy created by the daily activities of the human body is an accessible and natural energy source for nanogenerators. Fiber-structured functional materials contribute to the increase in energy efficiency due to their effective surface to volume ratio while providing the necessary compatibility and comfort for the movements in daily life with its flexibility and lightness. Among the potential solutions, electrospinning stands out as a promising technique that can meet these requirements, allowing for simple, versatile, and continuous fabrication. Herein, wearable electronics and their future potential, electrospinning, and its place in energy applications are overviewed. Moreover, piezoelectric, triboelectric, and hybrid nanogenerators fabricated or associated with electrospun fibrous materials are presented.
Citation - WoS: 4
Citation - Scopus: 8
Advances in Model-Based Testing of Graphical User Interfaces
(Elsevier Academic Press inc, 2017) Belli, Fevzi; Beyazit, Mutlu; Budnik, Christof J.; Tuglular, Tugkan; Tuğlular, Tuğkan; Bilgisayar Mühendisliği Bölümü
Graphical user interfaces (GUIs) enable comfortable interactions of the computer-based systems with their environment. Large systems usually require complex GUIs, which are commonly fault prone and thus are to be carefully designed, implemented, and tested. As a thorough testing is not feasible, techniques are favored to test relevant features of the system under test that will be specifically modeled. This chapter summarizes, reviews, and exemplifies conventional and novel techniques for model-based GUI testing.
Citation - WoS: 57
Citation - Scopus: 61
Amidoxime functionalized Polymers of Intrinsic Microporosity (PIM-1) electrospun ultrafine fibers for rapid removal of uranyl ions from water
(Elsevier Science Bv, 2019) Satilmis, Bekir; Isik, Tugba; Demir, Mustafa M.; Uyar, Tamer; Demir, Mustafa
The Polymers of Intrinsic Microporosity (PIM-1) is considered as one of the most promising polymer candidates for adsorption applications owing to its high surface area and the ability to tailor the functionality for the targeted species. This study reports a facile method for the preparation of amidoxime functionalized PIM-1 fibrous membrane (AF-PIM-FM) by electrospinning technique and its practical use for the extraction of U(VI) ions from aqueous systems via column sorption under continuous flow. Fibrous membrane form of amidoxime functionalized PIM-1 (AF-PIM-FM) was prepared by electrospinning method owing to its excellent processability in dimethylformamide. Bead-free and uniform fibers were obtained as confirmed by SEM imaging and average fiber diameter was 1.69 +/- 0.34 mu m for AF-PIM-FM. In addition, electrospun PIM-1 fibrous membrane (PIM-FM) was prepared as a control group. Structural and thermal characterization of powder and membrane forms of the materials were performed using FT-IR, H-1 NMR, XPS, Elemental analyses, TGA, and DSC. The porosity of the samples was measured by N-2 sorption isotherms confirming amidoxime PIM-1 still maintain their porosity after functionalization. Amidoxime functionality along with membrane structure makes AF-PIM-FM a promising material for uranyl adsorption. First, a comparison between powder and membrane form of amidoxime functionalized PIM-1 was investigated using batch adsorption process. Although membrane form has shown slightly lower adsorption performance in the batch adsorption process, the advantage of using the membrane in column adsorption processes makes membrane form more feasible for real applications. In addition, amidoxime modification enhanced the uranium adsorption ability of PIM-FM up to 20 times. The effect of initial concentration and pH were investigated along with regeneration of the adsorbents. AF-PIM-FM was successfully used for five adsorption-desorption cycles without having any damage on the fibrous structure.
Citation - WoS: 5
Analysis of adhesively bonded joints of laser surface treated composite primary components of aircraft structures
(Elsevier Sci Ltd, 2023) Nuhoglu, Kaan; Aktas, Engin; Tanoglu, Metin; Martin, Seckin; Iplikci, Hande; Barisik, Murat; Iris, Mehmet Erdem; Tanoğlu, Metin
The performance of the adhesively bonded aerospace structures highly depends on the adhesion strength between the adhesive and adherents, which is affected by, in particular, the condition of the bonding surface. Among the various surface treatment methods, as state of the art, laser surface treatment is a suitable option for the CFRP composite structures to enhance the adhesion performance, adjusting the roughness and surface free energy with relatively minimizing the damage to the fibers. The aim of this study is the validation and evaluation of the adhesive bonding behavior of the laser surface-treated CFRP composite structures, using the finite element technique to perform a conservative prediction of the failure load and damage growth. Such objectives were achieved by executing both experimental and numerical analyses of the secondary bonded CFRP parts using a structural adhesive. In this regard, to complement physical experiments by means of numerical simulation, macro-scale 3D FEA of adhesively bonded Single Lap Joint and Skin-Spar Joint specimens has been developed employing the Cohesive Zone Model (CZM) technique in order to simulate bonding behavior in composite structures especially skin-spar relation in the aircraft wing-box.
Citation - WoS: 12
Citation - Scopus: 14
Anomalous transmittance of polystyrene-ceria nanocomposites at high particle loadings
(Royal Soc Chemistry, 2013) Parlak, Onur; Demir, Mustafa M.; Demir, Mustafa
Optical nanocomposites based on transparent polymers and nanosized pigment particles have usually been produced at low particle concentrations due to the undesirable optical scattering of the pigment particles. However, the contribution of the particles to many physical properties is realized at high concentrations. In this study, nanocomposites were prepared with transparent polystyrene (PS) and organophilic CeO2 nanoparticles using various compositions in which the particle content was up to 95 wt%. The particles, capped by 3-methacryloxypropyltrimethoxysilane (MPS), were dispersed into PS and the transmittance of the spin-coated composite films was examined over the UV-visible region. When the particle concentration was <20 wt%, the transmittance of the films showed a first-order exponential decay as the Rayleigh scattering theory proposes. However, a positive deviation was observed from the decay function for higher particle contents. The improvement in transmittance may be a consequence of interference in the multiple scattering of light by the quasi-ordered internal microstructure that gradually develops as the particle concentration increases.
Citation - WoS: 8
An answer to colon cancer treatment by mesenchymal stem cell originated from adipose tissue
(Mashhad Univ Med Sciences, 2018) Iplik, Elif Sinem; Ertugrul, Baris; Kozanoglu, Ilknur; Baran, Yusuf; Cakmakoglu, Bedia; Baran, Yusuf
Objective(s): Colon cancer is risen up with its complex mechanism that directly impacts on its treatment as well as its common prevalence. Mesenchymal stem cells (MSCs) have been considered as a therapeutic candidate for conventional disease including cancer. In this research, we have focused on apoptotic effects of adipose tissue-derived MSCs in colon cancer. Materials and Methods: MSCs were obtained from adipose tissue and characterized by Flowcytometer using suitable antibodies. MSCs, HT-29, HCT-116, RKO and healthy cell line MRC5 were cultured by different seeding procedure. After cell viability assay, changes in caspase 3 enzyme activity and the level of phosphatidylserine were measured. Results: For cell viability assay, a 48 hr incubation period was chosen to seed all cells together. There was a 1.36-fold decrease in caspase 3 enzyme activity by co-treatment of RKO and MSCs in addition to 2.02-fold decrease in HT-29 and MSCs co-treatment, and 1.103-fold increase in HCT-116 and MSCs. The results demonstrated that HCT-116 led to the highest rate of apoptotic cell death (7.5%) compared with other cells. Conclusion: We suggest that MSCs might remain a new treatment option for cancer by its differentiation and repair capacity.
Citation - WoS: 59
Anti-proliferative, apoptotic and signal transduction effects of hesperidin in non-small cell lung cancer cells
(Springer, 2015) Cincin, Zeynep Birsu; Unlu, Miray; Kiran, Bayram; Bireller, Elif Sinem; Baran, Yusuf; Cakmakoglu, Bedia; Baran, Yusuf
Hesperidin, a glycoside flavonoid, is thought to act as an anti-cancer agent, since it has been found to exhibit both pro-apoptotic and anti-proliferative effects in several cancer cell types. The mechanisms underlying hesperidin-induced growth arrest and apoptosis are, however, not well understood. Here, we aimed to investigate the anti-proliferative and apoptotic effects of hesperidin on non-small cell lung cancer (NSCLC) cells and to investigate the mechanisms involved. The anti-proliferative and apoptotic effects of hesperidin on two NSCLC-derived cell lines, A549 and NCI-H358, were determined using a WST-1 colorimetric assay, a LDH cytotoxicity assay, a Cell Death Detection assay, an AnnexinV-FITC assay, a caspase-3 assay and a JC-1 assay, respectively, all in a time- and dose-dependent manner. As a control, non-cancerous MRC-5 lung fibroblasts were included. Changes in whole genome gene expression profiles were assessed using an Illumina Human HT-12v4 beadchip microarray platform, and subsequent data analyses were performed using an Illumina Genome Studio and Ingenuity Pathway Analyser (IPA). We found that after hesperidin treatment, A549 and NCI-H358 cells exhibited decreasing cell proliferation and increasing caspase-3 and other apoptosis-related activities, in conjunction with decreasing mitochondrial membrane potential activities, in a dose- and time-dependent manner. Through a GO analysis, by which changes in gene expression profiles were compared, we found that the FGF and NF-kappa B signal transduction pathways were most significantly affected in the hesperidin treated NCI-H358 and A549 NSCLC cells. Our results indicate that hesperidin elicits an in vitro growth inhibitory effect on NSCLC cells by modulating immune response-related pathways that affect apoptosis. When confirmed in vivo, hesperidin may serve as a novel anti-proliferative agent for non-small cell lung cancer.
Citation - WoS: 19
Apoptotic effects of non-edible parts of Punica granatum on human multiple myeloma cells
(Sage Publications Ltd, 2016) Kiraz, Yagmur; Neergheen-Bhujun, Vidushi S.; Rummun, Nawraj; Baran, Yusuf; Baran, Yusuf
Multiple myeloma is of great concern since existing therapies are unable to cure this clinical condition. Alternative therapeutic approaches are mandatory, and the use of plant extracts is considered interesting. Punica granatum and its derived products were suggested as potential anticancer agents due to the presence of bioactive compounds. Thus, polypenolic-rich extracts of the non-edible parts of P. granatum were investigated for their antiproliferative and apoptotic effects on U266 multiple myeloma cells. We demonstrated that there were dose-dependent decreases in the proliferation of U266 cells in response to P. granatum extracts. Also, exposure to the extracts triggered apoptosis with significant increases in loss of mitochondrial membrane potential in U266 cells exposed to the leaves and stem extracts, while the flower extract resulted in slight increases in loss of MMP. These results were confirmed by Annexin-V analysis. These results documented the cytotoxic and apoptotic effects of P. granatum extracts on human U266 multiple myeloma cells via disruption of mitochondrial membrane potential and increasing cell cycle arrest. The data suggest that the extracts can be envisaged in cancer chemoprevention and call for further exploration into the potential application of these plant parts.
Citation - WoS: 32
Apoptotic Effects of Quercitrin on DLD-1 Colon Cancer Cell Line
(Frontiers Media Sa, 2015) Cincin, Zeynep Birsu; Unlu, Miray; Kiran, Bayram; Bireller, Elif Sinem; Baran, Yusuf; Cakmakoglu, Bedia; Baran, Yusuf
Quercetin, which is the most abundant bioflavonoid compound, is mainly present in the glycoside form of quercitrin. Although different studies indicated that quercitrin is a potent antioxidant, the action of this compound is not well understood. In this study, we investigated whether quercitrin has apoptotic and antiproliferative effects in DLD-1 colon cancer cell lines. Time and dose dependent antiproliferative and apoptotic effects of quercitrin were subsequently determined by WST-1 cell proliferation assay, lactate dehydrogenase (LDH) cytotoxicity assay, detection of nucleosome enrichment factor, changes in caspase-3 activity, loss of mitochondrial membrane potential (MMP) and also the localization of phosphatidylserine (PS) in the plasma membrane. There were significant increases in caspase-3 activity, loss of MMP, and increases in the apoptotic cell population in response to quercitrin in DLD-1 colon cancer cells in a time- and dose-dependent manner. These results revealed that quercitrin has antiproliferative and apoptotic effects on colon cancer cells. Quercitrin activity supported with in vivo analyses could be a biomarker candicate for early colorectal carcinoma.
Citation - WoS: 18
Apoptotic Effects of Resveratrol, a Grape Polyphenol, on Imatinib-Sensitive and Resistant K562 Chronic Myeloid Leukemia Cells
(int inst Anticancer Research, 2012) Can, Geylani; Cakir, Zeynep; Kartal, Melts; Gunduz, Ufuk; Baran, Yusuf; Baran, Yusuf
Aim: To examine the antiproliferative and apoptotic effects of resveratrol on imatinib-sensitive and imatinib-resistant K562 chronic myeloid leukemia cells. Materials and Methods: Antiproliferative effects of resveratrol were determined by the 3-Bis[2-methoxy-4-nitro-5-sulphophenyl]-2H-tetrazolium-5-carboxanilide inner salt (XTT) cell proliferation assay. Apoptotic effects of resveratrol on sensitive K562 and resistant K562/IMA-3 cells were determined through changes in caspase-3 activity, loss of mitochondrial membrane potential (MMP), and apoptosis by annexin V-(FITC). Results: The concentrations of resveratrol that inhibited cell growth by 50% (IC50) were calculated as 85 and 122 mu M for K562 and K562/IMA-3 cells, respectively. There were 1.91-, 7.42- and 14.73-fold increases in loss of MMP in K562 cells treated with 10, 50, and 100 mu M resveratrol, respectively. The same concentrations of resveratrol resulted in 2.21-, 3.30- and 7.65-fold increases in loss of MMP in K562/IMA3 cells. Caspase-3 activity increased 1.04-, 2.77- and 4.8-fold in K562 and 1.02-, 1.41- and 3.46-fold in K562/IMA3 cells in response to the same concentrations of resveratrol, respectively. Apoptosis was induced in 58.7%- and 43.3% of K562 and K562/IMA-3 cells, respectively, in response to 100 mu M resveratrol. Conclusion: Taken together these results may suggest potential use of resveratrol in CML, as well as in patients with primary and/or acquired resistance to imatinib.
Citation - WoS: 1
Citation - Scopus: 1
Application of Human-Robot Interaction Features to Design and Purchase Processes of Home Robots
(Springer international Publishing Ag, 2021) Yapici, Nur Beril; Tuglular, Tugkan; Basoglu, Nuri; Tuğlular, Tuğkan; Bilgisayar Mühendisliği Bölümü
Production of home robots, such as robotic vacuum cleaners, currently focuses more on the technology and its engineering than the needs of people and their interaction with robots. An observation supporting this view is that the home robots are not customizable. In other words, buyers cannot select the features and built their home robots to order. Stemmed from this observation, the paper proposes an approach that starts with a classification of features of home robots. This classification concerns robot interaction with humans and the environment, a home in our case. Following the classification, the proposed approach utilizes a new hybrid model based on a built-to-order model and dynamic eco-strategy explorer model, enabling designers to develop a production line and buyers to customize their home robots with the classified features. Finally, we applied the proposed approach to robotic vacuum cleaners. We developed a feature model for robotic vacuum cleaners, from which we formed a common uses scenario model.
Citation - WoS: 2
Citation - Scopus: 1
Application of the Law of Minimum and Dissimilarity Analysis to Regression Test Case Prioritization
(Ieee-inst Electrical Electronics Engineers inc, 2023) Ufuktepe, Ekincan; Tuglular, Tugkan; Tuğlular, Tuğkan; Bilgisayar Mühendisliği Bölümü
Regression testing is one of the most expensive processes in testing. Prioritizing test cases in regression testing is critical for the goal of detecting the faults sooner within a large set of test cases. We propose a test case prioritization (TCP) technique for regression testing called LoM-Score inspired by the Law of Minimum (LoM) from biology. This technique calculates the impact probabilities of methods calculated by change impact analysis with forward slicing and orders test cases according to LoM. However, this ordering doesn't consider the possibility that consecutive test cases may be covering the same methods repeatedly. Thereby, such ordering can delay the time of revealing faults that exist in other methods. To solve this problem, we enhance the LoM-Score TCP technique with an adaptive approach, namely with a dissimilarity-based coordinate analysis approach. The dissimilarity-based coordinate analysis uses Jaccard Similarity for calculating the similarity coefficients between test cases in terms of covered methods and the enhanced technique called Dissimilarity-LoM-Score (Dis-LoM-Score) applies a penalty with respective on the ordered test cases. We performed our case study on 10 open-source Java projects from Defects4J, which is a dataset of real bugs and an infrastructure for controlled experiments provided for software engineering researchers. Then, we hand-seeded multiple mutants generated by Major, which is a mutation testing tool. Then we compared our TCP techniques LoM-Score and Dis-LoM-Score with the four traditional TCP techniques based on their Average Percentage of Faults Detected (APFD) results.
Citation - WoS: 0
An Architecture for Verification of Access Control Policies with Multi Agent System Ontologies
(Ieee, 2009) Tekbacak, Fatih; Tuglular, Tugkan; Dikenelli, Oguz; Tuğlular, Tuğkan; Bilgisayar Mühendisliği Bölümü
Multi-agent systems (MAS) which communicate with intra-domain and inter-domain agent platforms have access control requirements. Instead of a central mechanism, a fine-graned access control mechanism could have been applied to MAS platforms. This paper emphasizes MAS-based domain and security ontologies with XACML-based access control approach for MAS platforms. The domain dependent behaviour and access control parameters in agent ontologies could be combined within a common XACML policy documents should be consistent to enforce policies for MAS. To obtain this conditions. Agent-based access control requirements and common XACML policy documents should be consistent to enforce policies for MAS. To obtain this condition, the translation of organizational policies and platform based policies have to be considered in derail and the verified policy features have to be enforced in MAS to provide access for resources.
Citation - WoS: 34
Autologous rabbit adipose tissue-derived mesenchymal stromal cells for the treatment of bone injuries with distraction osteogenesis
(Elsevier Sci Ltd, 2013) Sunay, Ozgur; Can, Geylani; Cakir, Zeynep; Denek, Ziya; Kozanoglu, Ilknur; Erbil, Guven; Baran, Yusuf; Baran, Yusuf
Background aims. Adipose tissue-derived mesenchymal stromal cells (MSCs) have a higher capacity for proliferation and differentiation compared with other cell lineages. Although distraction osteogenesis is the most important therapy for treating bone defects, this treatment is restricted in many situations. The aim of this study was to examine the therapeutic potential of adipose tissue-derived MSCs and osteoblasts differentiated from adipose tissue-derived MSCs in the treatment of bone defects. Methods. Bone defects were produced in the tibias of New Zealand rabbits that had previously undergone adipose tissue extraction. Tibial osteotomy was performed, and a distractor was placed on the right leg of the rabbits. The rabbits were placed in control (group I), stem cell (group II) and osteoblast-differentiated stem cell (group III) treatment groups. The rabbits were sacrificed, and the defect area was evaluated by radiologic, biomechanical and histopathologic tests to examine the therapeutic effects of adipose tissue-derived MSCs. Results. Radiologic analyses revealed that callus density and the ossification rate increased in group III compared with group I and group II. In biomechanical tests, the highest ossification rate was observed in group III. Histopathologic studies showed that the quality of newly formed bone and the number of cells active in bone formation were significantly higher in group III rabbits compared with group I and group II rabbits. Conclusions. These data reveal that osteoblasts differentiated from adipose tissue-derived MSCs shorten the consolidation period of distraction osteogenesis. Stem cells could be used as an effective treatment for bone defects.
Citation - WoS: 0
Automatic Code Generation with Document Responsibility Collaboration Modelling Method
(Ieee, 2020) Tuglular, Tugkan; Leblebici, Onur; Tuğlular, Tuğkan; Bilgisayar Mühendisliği Bölümü
UML is highly preferred for design in current software development approaches. However, the conceptual gap between entities in business processes and classes in UML designs is not small. To reduce this gap, this paper proposes using documents that are vital to every business. The proposed new method called Document Responsibility Collaboration puts the concept of documents at the center. In the proposed method, documents are meta-models of classes in terms of programming, and at the same time, they are meta-models of relationships in terms of permanence. The proposed Document Responsibility Collaboration method uses the domain concept in which domains are made up of documents, and a document defined in a domain can work with another document in any domain to fulfill its responsibility. Document Responsibility Collaboration method defines a process, which starts at the transition from analysis to design phase and continues to the code generation phase. An example from the order management domain is provided to validate the recommended method.
Citation - WoS: 1
Automatic enforcement of location aware user based network access control policies
(World Scientific and Engineering Acad and Soc, 2008) Tuglular, Tugkan; Tuğlular, Tuğkan; Bilgisayar Mühendisliği Bölümü
Multiple interconnected network segments distributed across various locations, such as corporate networks, where users or employees constantly travel among segments and require to access servers, need to have network access control mechanisms that are able to adapt to these location changes. The idea of a firewall changing or adapting its rules depending on the location of users is presented by an architecture in this paper. This architecture proposes deployment of a policy server at the management level and policy agents at the firewall level, so that policy-driven network security management is enabled by specifying location aware user based network access control policies at the network security management and enforcing them at the managed firewalls. The architecture presented in this paper utilizes user VPN connection event triggers for dynamic policy configuration and automated policy deployment to firewalls. Location aware user based network access control policies, which are management level policies, are implemented using XACML. A network level policy is usually a configuration, or policy, file local to the firewall. The policy agent incorporated into the firewall performs the mapping from management level policy to firewall policy.
Citation - WoS: 1
Citation - Scopus: 5
Automation Architecture for Bayesian Network Based Test Case Prioritization and Execution
(Ieee, 2016) Ufuktepe, Ekincan; Tuglular, Tugkan; Tuğlular, Tuğkan; Bilgisayar Mühendisliği Bölümü
An automation architecture for Bayesian Network based test case prioritization is designed for software written in Java programming language following the approach proposed by Mirarab and Tahvildari [2]. The architecture is implemented as an integration of a series of tools and called Bayesian Network based test case prioritization and execution platform. The platform is triggered by a change in the source code, then it collects necessary information to be supplied to Bayesian Network and uses Bayesian Network evaluation results to run high priority unit tests.
Citation - WoS: 0
Autophagic and Apoptotic Effects of Tyrosine Kinase Inhibitors in Myeloid Leukemia: Comparison of Three Generation
(Amer Soc Hematology, 2012) Kayabasi, Cagla; Avci, Cigir Biray; Susluer, Sunde Yilmaz; Balci, Tugce; Baran, Yusuf; Saydam, Guray; Gunduz, Cumhur; Baran, Yusuf
[No Abstract Available]
Citation - WoS: 8
Bioactive sphingolipids in docetaxel-induced apoptosis in human prostate cancer cells
(Elsevier France-editions Scientifiques Medicales Elsevier, 2012) Bassoy, Esen Yonca; Baran, Yusuf; Baran, Yusuf
In this study, we examined the possible roles of ceramide/sphingosine-1-phosphate and ceramide/glucosyleceramide signaling in docetaxel-induced apoptosis by examining expression levels of the glucosyleceramide synthase and sphingosine kinase-1 and ceramide synthase gene family. As confirmed by isobologram analysis, docetaxel in combination with agents that increase intracellular ceramide levels increased the cytotoxic and apoptotic effects of docetaxel synergistically. More importantly, RT-PCR results revealed that expression levels of glucosyleceramide synthase and sphingosine kinase-1 were downregulated and ceramide synthase genes were upregulated in response to docetaxel. This study identifies mechanisms underlying the involvement of ceramide metabolizing genes in docetaxel-induced apoptosis in prostate cancer cells. (c) 2012 Elsevier Masson SAS. All rights reserved.

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